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KMID : 0360319940260040534
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 4 p.534 ~ p.543
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The Prognosis and Expression of p53, c-erb-2 in Gastric Cancer Patients
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김영돈
이종인/김용규/문난모/백남선/최동욱/황대용/장자준/양한광
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Abstract
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Authors studied the overexpression of p53 and c-erbB-2 in 278 gastric cancer patients who were operated in KCCH from 1985 Jan. to 1987 Jan., by immunohistochemical staining using archival paraffin embedded tissue and the possibility of them as
prognostic factors. Overall overexpression rate was 39.2% for p53 and 15.1% for c-erbB-2 respectively. There were no differences in overexpression rate according to sex, age, Borrmann type, depth of tumor, nodal metastasis, growth pattern,
lymphatic or
venous invasion, tumor size and distant organ metastasis in both p53 and c-erbB-2. The overexpression rate of c-erbB-2 of well of moderately differentiated type and that of Lauren's intestinal type were higher than that of poorly differentiated
type and
diffuse type. Overall cumulative five year survival rates of positive group for p53 and c-erbB-2 were slightly lower than those of negative group, but the differences of them were not significant. However, cumulative five year survival rate of
positive
group for c-erbB-2 in intestinal type cancer was lower than that of negative group significantly (0.0351). So, we suggest that c-erbB-2 overexpression could be a prognostic factor in gastric cancer, especially in intestinal type.
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